Here, the challenge was achieving nuclear delivery. By conjugating MIRD226 to a TAT peptide, the construct overcame nuclear export via XPO1. This made MIRD226 better at silencing MET oncogene, leading to a 70% reduction in cell migration in vitro.
Download the MIRD226 Optimization Checklist (available from most major oligo suppliers) to benchmark your current protocol against the "better" standard. mird226 better
It uses approximately 15% less power than the MIRD226 competitors. Here, the challenge was achieving nuclear delivery
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