Hmn147 Work __full__ Jun 2026

The mutation disrupts the SAX-7 protein, which is essential for neurons to "stick" to their surroundings.

strain to investigate "retrograde extension," a process where dendrites (the "branches" of a neuron) anchor themselves to a specific location while the rest of the cell body moves away. Significance : Without a functional gene (as seen in hmn147 work

After a heart attack, excessive scarring can lead to heart failure. Hmn147 work appears to limit fibroblast-to-myofibroblast transition without impairing necessary scar formation—a delicate balance that many anti-fibrotic drugs cannot achieve. The mutation disrupts the SAX-7 protein, which is

The 2020 Development paper by Cebul et al. identifies the hmn147 allele as a mutation in the sax-7 (L1CAM) gene, which disrupts neuronal anchoring to glia in C. elegans . This study demonstrates that SAX-7 and GRDN-1 are critical for retrograde dendrite extension, allowing sensory neurons to maintain glial attachment during body growth. Read the full paper at Development . elegans