The story unfolds almost entirely within the confines of a family-run morgue. Tony Tilden (Brian Cox) and his son Austin (Emile Hirsch) are coroners who receive a mysterious "Jane Doe"—an unidentified woman found at a bizarre crime scene where there are no signs of forced entry, yet multiple bodies are present.

The film's popularity in various formats, including versions with Hindi dubbing or subtitles, is due to its unique approach to the genre:

The Autopsy of Jane Doe (2016) : A Deep Dive into Atmospheric Horror