In her personal life, Madhuri Dixit has been married to Dr. Sujit Vaidya, a cardiovascular surgeon, since 1999. The couple has two children, Aryan and Arin. Despite her busy schedule, Madhuri Dixit has been actively involved in various charitable initiatives, including the National AIDS Control Board and the Akshaya Patra Foundation.

During the peak of her stardom in the late 1980s and early 90s, Madhuri's personal life was a frequent subject of media speculation.