Save Cheat Engine for old, offline, unsupported games where it was intended. For Trailmakers , the only engine you need is the one you build yourself.
Knowing this, I can suggest if a simple sandbox setting or a specific trainer is better for you. i--- Trailmakers Cheat Engine
: Start Trailmakers and then open the Cheat Engine. You'll need to select the game process from the Cheat Engine's process list. Save Cheat Engine for old, offline, unsupported games