There is a nuance here. If you are strictly looking to mod GTA 5 Story Mode on an Xbox One, there are limited, extremely technical methods involving a modded console (JTAG/RGH) and a USB drive. However, those consoles are rare, expensive, and get banned from Xbox Live instantly.

While some players have been exploring ways to use mod menus on Xbox One using a USB device, the process can be complex and comes with risks. Additionally, the limited mod support on Xbox One can restrict the types of mods available.